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Made from Griffonia simplicifolia
Precursor of melatonin
Precursor of serotonin
60 vegetarian capsules; 100 mg per capsule

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EUR 16.95
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Doctors Best

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Product Description


5-hydroxytryptophan (5-HTP) is a naturally occurring amino acid and functions as an antioxidant in the body, but also, inter alia, as an essential precursor of the neurotransmitter serotonin. After intake of 5-HTP the molecule easily crosses the blood-brain barrier, and is incorporated in the central nervous system. Here it does its work through a specific route that transforms 5-HTP to serotonin. Serotonin is subsequently used in, among other things, the production of melatonin.

In 1960, chemical studies showed that
Griffonia simplicifolia seeds contained several "indole" derivatives including 5-hydroxy-L-tryptophan (also known as oxitriptan) and L-5-HTP, also known as 5-HTP.

After isolation and identification of the 5-HTP molecule Griffonia simplicifolia seeds attained a lot of attention given its high concentrations. Studies from the period 1970-1980, the effect of 5-HTP were mapped in detail, and in 1980 the first products appeared on the market.

In 1989, a ban took effect in the United States on products containing L-tryptophan because of health risks from polluted supplements. This prohibition was an additional incentive for the popularity of 5-HTP as it is a direct alternative to

Moreover, it is important not to confuse 5-HTP and L-tryptophan. Although L-tryptophan is the direct precursor of 5-HTP, it is also metabolized into a range of other chemical compounds. 5-HTP, on the other hand, can only be used for the production of serotonin. Furthermore, 5-HTP works faster than L-tryptophan and may offer additional benefits.

Griffonia simplicifolia (also called Bandeiraea simplicifolia) is one of the traditional herbs acquired in the Western Africa. This plant has been used, particularly in western and central Africa, for a variety of indications. Before capsules or supplements were available, Griffonia simplicifolia extracts were made from the pulp of the bark and used in traditional medicine. The stem and leaves also contain active elements. Chewing on the trunk is a common way to take advantage of the active ingredients.

In addition to its role as a traditional herb, the Griffonia simplicifolia plant also plays other roles in the daily life of the people of Ghana. The timber, for example, is widely used as a walking stick because of its strong structure, women make a face powder using the roots, and the leaves are used in the production of black dye.

Supplements mainly contain the chemical compounds of the seeds of this plant. Ripe seeds contain about 6-14% of 5-HTP. They are harvested annually. The processing of the seeds is similar to the processing of cocoa, and often the same production equipment is used for this purpose. The semi-finished product from this process forms the basis for the more pure extracts, which are ultimately incorporated into the capsules.

Additional Information

Name 5-HTP
Brand Doctors Best
Content 60 capsules
User Instructions Take 1 capsule daily, with or without food, or as recommended by a nutritionally-informed physician.
Serving Size 1 capsule
Ingredients per Serving 100 mg 5-HTP (5-hydroxytryptophan from Griffonia simplicifolia seed extract) †. † Recommended Daily Intake not established.
Other Ingredients Modified cellulose (capsule), rice powder, magnesium stearate (vegetable source).
Allergens Does not contain soy, wheat, gluten, lupine, peanuts, celery, mustard, nuts, sesame, milk, egg, fish, crustaceans or molluscs.
Suitable for vegans Yes
Suitable for vegetarians Yes
Gluten free Yes
Certified Organic N/A


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