Methylfolate Quatrefolic 90 capsules.

400 µg folate as (6S)-5-methyltetrahydrofolate (Quatrefolic®) and 40 mg vitamin C per capsule. One capsule a day, vegan.

Why this product?

400 µg folate as methylfolate (Quatrefolic®)

The 6S form of 5-MTHF

Optimally absorbed, suitable when trying to conceive and during pregnancy

1 capsule a day, preferably between meals

Vegan, 90 capsules

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90 capsules · 90 days · €0.19 per day
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Fully Active Folate - Quatrefolic® - 90 capsules

Methylfolate Quatrefolic 90 capsules.

Order before 22:00, processed the same day
Free shipping from €85.00
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€16,95
€0,18 per serving
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01 / The story

Folate in the form that circulates in your blood.

01, The story
02, Form & figures
03, Ingredients & dosage
04, What we may claim
05, Quality & production
06, Frequently asked questions
Reading time · 6 min

Methylfolate by Doctor's Best contains 400 µg folate as (6S)-5-methyltetrahydrofolate (Quatrefolic®), a stable, natural form that is optimally absorbed, with 40 mg vitamin C. Doctor's Best calls it suitable for women who want to become pregnant or are pregnant: folate contributes to the formation of the placenta and the growth of the unborn child. One capsule a day. Vegan.

Mirror images: 6S and 6R

Methylfolate exists in two forms that are mirror images of each other, just like a left and a right hand: 6S and 6R. Only the 6S form occurs in food and in the body. Quatrefolic® from the Italian company Gnosis is the 6S form, bound to glucosamine to keep the substance stable.

Made in the United States

Doctor's Best makes Methylfolate in the United States, with Quatrefolic® as the raw material and a plant-based capsule. The glucosamine salt is of plant origin, so the product is vegan.

Facts about this product

One capsule provides 400 µg folate, 200% of the reference intake, and 40 mg vitamin C. Preferably take the capsule between meals.

Methylfolate by Doctor's Best

Methylfolate with Quatrefolic® is a very stable, natural form of folic acid that is optimally absorbed by the body. This B vitamin, vitamin B11, is very essential for all kinds of bodily processes. It benefits pregnant women because it contributes to the growth of the unborn child, it has a beneficial effect on the immune system, on the production of blood cells, on cell renewal, it supports fatigue and stress, and it contributes to a normal homocysteine metabolism. In some countries, folic acid is called vitamin B9.

Quatrefolic® methylfolate is stable

Folic Acid, Folate, and Quatrefolic® Methylfolate (5-MTHF) are different forms of Vitamin B11 often confused by consumers and even by medical or nutrition professionals. However, absorption within the body is different, and so are the effects on the body.

Benefits

Folic acid contributes to the formation of the placenta. Folic acid contributes to the growth of the unborn child. Folic acid contributes to resilience to stress. Folic acid contributes to normal psychological functioning. Folic acid contributes to the reduction of fatigue. Folate contributes to normal amino acid synthesis. Folic acid supports the immune system. Folic acid supports the production of red and white blood cells. Folic acid contributes to the process of cell renewal. Folic acid contributes to normal homocysteine metabolism. Does not contain gluten; GMO-free. Suitable for vegans and vegetarians.

What is the difference between folic acid and folate?

Folic acid, or pteroylmonoglutamic acid, is the synthetic, oxidized form of the natural though unstable folate (tetrahydrofolate). Folate is found in food and is used by the body. Folic acid is very stable and is therefore widely used in dietary supplements. Folic acid must be converted in the body across several steps before it can be used. First it is converted into tetrahydrofolate and then, via a methylation cycle, into the active form of 5-methyltetrahydrofolate (5-MTHF). This enzyme requires certain enzymes: the so-called MTHFR enzyme activity. Quatrefolic® methylfolate (5-MTHF) can support this activity. The body can therefore directly use this active form of B11. Quatrefolic® is a very stable form of folate with a high bioavailability.

During pregnancy or family planning, and for the elderly

Methylfolate from Doctor's Best contains only natural methylfolate from the Quatrefolic® brand. Due to its safety profile and excellent absorption, this product is very suitable for target groups with an increased need for folic acid / folate, including women who want to become pregnant, women who are already pregnant, as well as elderly.

5-MTHF is an important methyl donor

5-MTHF is an important source of the body for what are called methyl groups (CH3). Methyl groups are essential in a process called methylation, which happens continuously in every cell in the body. Methylation is a controlled transfer of a methyl group (CH3: one carbon and three hydrogen atoms) to proteins, amino acids, enzymes and DNA. Via methylation, the functioning of the body is regulated through numerous biochemical processes and metabolic pathways. Thus, 5-MTHF methyl groups are essential for numerous life processes throughout the body.

Guaranteed 6 (S) -5-methyltetrahydrofolate

Folate can be found on the market under various names in various supplements. However, only the L and 6 (S) forms are bioactive. The D and 6 (R) forms are not bioactive. Doctor's Best Methylfolate with Quatrefolic® contains the active form of 6 (S)-5-methyltetrahydrofolate.

About Doctor's Best

Doctor's Best produces high-quality food supplements based on scientific research into good nutrition. The raw materials for the products are grown, developed and researched worldwide. Doctor's Best works together with nutrition scientists to produce strictly high-quality, highly effective supplements. Only branded raw materials are used and supplements have been thoroughly tested during every step of the production process, from raw material to end product. The manufacturing process is integrally based on the Guidelines for Current Good Manufacturing Practice (cGMP). Doctor's Best was founded in 1990 by a physician with an interest in wholesome nutrition. The company’s product range now includes more than 200 items.

Standardized brand products

In its products Doctor's Best almost exclusively uses proprietary and standardized brand materials of official trademarks that have been extensively researched. The authenticity of these ingredients is guaranteed in all products. Doctor's Best never uses alternatives. This results in a qualitatively superior line of supplements with very high bioavailability.

02 / Form & figures

Figures from the label.

Per capsule, the daily dose as stated by Doctor's Best.

400 µg
Folate
200% of the reference intake.
40 mg
Vitamin C
50% of the reference intake.
1
Capsule per day
Between meals.
90
Days
90 capsules at 1 per day.
Ingredients and use

Per capsule.

Per capsule Amount %RI Form
Folate 400 µg200% (6S)-5-methyltetrahydrofolate, glucosamine salt (Quatrefolic®)
Vitamin C 40 mg50% Ascorbic acid

Label · other ingredients: glucosamine salt (plant source), vegetable capsule (modified cellulose), cellulose · dosage: 1 capsule per day, preferably between meals · net contents 90 capsules · RI = reference intake

Product information

How to use it. And everything on the label.

How to use

Take 1 capsule daily, preferably between meals, or as recommended by a nutritionist doctor.

Contents
90 capsules
Allergens
None
Other ingredients
Glucosamine salt (vegetable source), modified cellulose (capsule), cellulose.
Storage
Store in a cool, dry and dark place.
Do not exceed the recommended daily dose.
Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle.
Keep out of the reach of young children.
* RI = reference intake according to European standards.

Reviews

What we may claim

Claims for folate and vitamin C.

Framework
EU 432/2012
EFSA register
Subject
Folate and vitamin C
(1 capsule per day)

In Europe, we may only make health claims about food supplements that have been assessed and authorised by the EFSA and are listed in the official EU register.

The authorised claims for folate and vitamin C are listed below, word for word as in the register. The other descriptions on this page come from the product information of Doctor's Best.

Folate contributes to maternal tissue growth during pregnancy.

EFSA · AUTHORISED HEALTH CLAIM

Folate contributes to normal blood formation.

EFSA · AUTHORISED HEALTH CLAIM

Folate contributes to the normal function of the immune system.

EFSA · AUTHORISED HEALTH CLAIM

Folate contributes to the reduction of tiredness and fatigue.

EFSA · AUTHORISED HEALTH CLAIM

Folate contributes to normal psychological function.

EFSA · AUTHORISED HEALTH CLAIM

Folate contributes to normal homocysteine metabolism.

EFSA · AUTHORISED HEALTH CLAIM

Folate contributes to normal amino acid synthesis.

EFSA · AUTHORISED HEALTH CLAIM

Folate has a role in the process of cell division.

EFSA · AUTHORISED HEALTH CLAIM

Vitamin C contributes to the normal function of the immune system.

EFSA · AUTHORISED HEALTH CLAIM
AND WHAT WE ARE NOT ALLOWED TO SAY
  • -
    No claim whatsoever about curing, preventing or treating diseases. A supplement is not a medicine and we do not present it as one.
  • -
    No substitute for medical advice. If you take medication, are pregnant or have a medical condition, consult your doctor.
  • -
    No substitute for a varied diet. A supplement is an addition to healthy eating, not an alternative.
AWAITING ASSESSMENT

A scientific assessment by the EFSA is still ongoing for a number of plant substances. Claims for these may be used under a transitional arrangement and are marked on this page as on hold.

Professionally reviewed

Read and checked by a fellow professional.

Diederik Jansen

Independent researcher · editorial review

The content of this page has been checked for factual accuracy, from the composition to compliance with the European rules on health claims.

The content of this page has been checked for factual accuracy, from the composition to compliance with the European rules on health claims.

Curator's note
400 µg folate in the 6S form, with a little vitamin C.
Selected by Ergomax

Methylfolate as Quatrefolic®, a dose that corresponds to the usual advice of 400 µg per day.

If you are pregnant or want to become pregnant, discuss with your midwife or doctor which form and how much folate suits you. Do not combine with other supplements containing folate without consultation.

About the brand

Doctor's Best, briefly explained.

Doctor's Best

Branded raw materials with a name.

Doctor's Best is an American supplement brand, founded in 1990. The range comprises more than 200 products. A distinctive feature is that the brand often works with raw materials from specialised suppliers that are sold under their own brand name, such as MenaQ7®, Suntheanine® and OptiMSM®. As a result, the label shows exactly which raw material is inside.

All products from Doctor's Best
Quality and production

Branded ingredients, tested at every step.

Doctor's Best often uses branded ingredients: raw materials from specialised suppliers, delivered under their own brand name, such as MenaQ7® and OptiMSM®. That way you know exactly which ingredient you are getting. All products are made according to cGMP, the American guidelines for good manufacturing practice.

Raw materials 01
Branded ingredients
Such as MenaQ7® and OptiMSM®
Production 02
According to cGMP
Current Good Manufacturing Practice
Testing 03
Tested at every step
From raw material to end product
Range 04
More than 200 products
Since 1990
08 / Frequently asked questions

What you still wanted to know.

Folate contributes to maternal tissue growth during pregnancy, normal blood formation, the normal function of the immune system and the reduction of tiredness. One capsule provides 400 µg folate, 200% of the reference intake.

The glucosamine salt form of (6S)-5-methyltetrahydrofolate, developed by the Italian company Gnosis. It is the active form of folate, which the body no longer needs to convert. The glucosamine in this salt is plant-derived, not from shellfish.

One capsule a day, preferably between meals. A jar of 90 capsules lasts three months. In addition to folate, each capsule contains 40 mg vitamin C. The product is vegan.

Health authorities advise women who are trying to conceive and in early pregnancy to take 400 µg folic acid a day. Ask your midwife or doctor whether methylfolate is a good choice for you.

Folic acid is a synthetic, stable form of folate that the body converts in a number of steps. Methylfolate (5-MTHF) is the form in which folate circulates in the blood. Both fall under the same authorised claims for folate. In the Netherlands, the advice for women who want to become pregnant is 400 µg folic acid per day.

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09 / Combines well with

A routine, not a standalone product.

Folate and vitamin B12 work together in the same metabolism. Fully Active B12 by Doctor's Best complements the methylfolate.

Methylfolate Quatrefolic supplement in its packaging
Methylfolate Quatrefolic
Fully Active B12 capsules - 1500 mcg, pack of 60 capsules
Fully Active B12
Folate and B12

Methylfolate and B12.

  • Folate contributes to normal blood formation
  • Vitamin B12 contributes to normal red blood cell formation
The claims mentioned are authorised by the EFSA and apply at the recommended daily dose.
€29,90

Methylfolate Quatrefolic €16,95 + Fully Active B12 €12,95